The Big Unlock

14 episodes scanned. 33% of ad slots promote the show's own products.

Recent Episodes

1. Episode 233 – In the Age of AI, Healthcare Privacy Goes Beyond HIPAA

   Nov 3, 2026

   Lucia C. Savage, a healthcare regulation and privacy expert who previously served as chief privacy officer at the Office of the National Coordinator for Health IT and retired from Omada Health in 2026, discusses why HIPAA does not cover consumer health apps and how state privacy laws, now in 23 states, fill that gap. The conversation covers de-identification risks from AI, the data lifecycle, patient consent for ambient AI scribes, and guardrails against AI tools posing as licensed professionals. She also addresses patients using AI for their own health and her view that responsible development can become a competitive advantage.

2. Episode 232 – The Real Measure of Healthcare AI Is Value, Not Volume

   Oct 28, 2026

   Daniel Barchi, CIO of CommonSpirit Health, discusses how the system grew its AI portfolio to about 260 applications while retiring underperforming tools and tracking realized rather than projected ROI. The conversation covers AI governance with a multidisciplinary committee, a five-gate value-tracking process, the split between built, platform, and purchased tools, and the Insightli walled-garden platform for secure LLM access. Barchi also addresses workforce training, clinician burnout, and his view that healthcare transformation is primarily about people and process.

3. Episode 231 – Healthcare Innovation Demands a Culture That Fears Inaction, Not Failure

   Oct 20, 2026

   Dr. Richard Zane, Chief Medical Officer and Chief Innovation Officer at UCHealth, discusses how AI and other technologies can support clinical decision-making and extend care to rural communities. He describes UCHealth's Care Innovation Center model of co-developing solutions with technology companies, what he looks for in startups, and how the health system pursues phased deployments and rapid iteration. The conversation also covers AI governance, clinician adoption of tools like OpenEvidence, and the cultural principles behind his approach to failure and innovation.

4. Episode 230 – AI Could Drive a Scope of Practice Change in Healthcare

   Oct 13, 2026

   Hal Wolf, President and CEO of HIMSS, discusses how AI is changing healthcare's approach to digital maturity, workforce shortages, and care delivery. He addresses the digital divide, arguing that emerging technologies initially favor well-resourced organizations but become more accessible through standardization and competition. He also describes how continuous data from wearables and AI monitoring could shift clinical scope of practice, and why governance, measurable outcomes, and human oversight remain essential.

5. Episode 229 – Agentic AI Can Expand Access to Primary Care

   Oct 6, 2026

   Jean-Claude Saghbini, CTO and President of Technology Services at Lumeris, discusses how agentic AI can address healthcare's critical primary care access gap. He introduces Tom, Lumeris' AI-powered primary care team member and operating system, which uses patient data to identify next actions and proactively engage patients between visits. Saghbini emphasizes that competitive advantage in healthcare AI comes not from models themselves, but from data, domain knowledge, integrated applications, and redesigned workflows—and warns against automation, pilot, and perfection traps.

6. Episode 228 – AI-Powered Health Discovery and the Path to Care

   Sep 29, 2026

   Ann Bilyew, President of WebMD Ignite, discusses how AI-generated health information is fundamentally reshaping healthcare marketing and patient engagement. She argues that as LLMs increasingly control the information layer, health systems must shift focus from owning search rankings to establishing credibility, earning citations from AI models, and owning the handoff from patient question to actual care. Bilyew emphasizes the importance of complete, corroborated content and personalized engagement tailored to individual patient circumstances, while highlighting the critical need to break down organizational silos between marketing, clinical education, and care delivery.

7. Episode 227 – AI-Native Means Rethinking the Workflow, Not Bolting on AI

   Sep 22, 2026

   Don Woodlock, President of InterSystems, discusses how healthcare organizations must move beyond bolting AI onto existing systems to truly embrace AI-native architectures. He emphasizes that effective AI implementation requires attention to three critical areas: use cases and ROI, change management, and backend data integration. Woodlock argues that healthcare remains fundamentally human-centered, with AI serving to support rather than replace clinical decision-making, and explores how agentic AI can reduce administrative burden while maintaining human oversight.

8. Episode 226 – Healthcare AI Requires Workflow Transformation, Not Just Technology

   Sep 16, 2026

   Roberta Schwartz, Executive Vice President and Chief Innovation Officer at Houston Methodist Hospital, discusses how healthcare organizations must move beyond AI hype toward outcomes-driven innovation that requires workflow transformation, not just technology deployment. She shares Houston Methodist's approach to evaluating AI and agentic technologies through a center of innovation that brings together IT leaders and operators to measure impact on care quality, workforce satisfaction, and cost reduction. Key examples include a 95% patient satisfaction scheduling bot (Zoe) that required process redesign before technology implementation, and expansion of virtual care and centralized specialty services to address access challenges. Schwartz emphasizes that successful AI adoption requires skepticism, clearly defined trials, rigorous outcome measurement, and a commitment to improving care, strengthening the workforce, and reducing costs simultaneously.

9. Episode 225 – Moving Healthcare AI from Conversation to Execution

   Sep 8, 2026

   Shailu Verma, CEO and Co-founder of Mila Health, discusses how healthcare AI is transitioning from conversational tools to executable AI agents that automate care coordination workflows. He explains Mila's API-first architecture that embeds directly into existing clinical software systems, enabling rapid deployment across 300+ dental organizations. Verma emphasizes that successful AI implementation requires focus on measurable ROI, human-in-the-loop safeguards, and solving specific operational problems like patient outreach and appointment scheduling rather than pursuing broad point solutions.

10. Episode 224 – AI Can Augment Clinical Judgment Without Replacing It

    Sep 1, 2026

    Dr. Ami Bhatt, Chief Medical Officer at WHOOP and former Chair of the FDA Digital Health Advisory Committee, discusses how healthcare can leverage AI to augment—not replace—clinical judgment. She emphasizes that AI serves as a source of compute power to surface knowledge and identify patterns, while clinical acumen remains central to decision-making. The conversation covers patient-centered design, agentic AI guardrails, post-deployment monitoring, real-world evidence, and the need for healthcare leaders to prepare for constant technological change.