The Big Unlock

Recent Episodes

1. Episode 219 – Health Literacy is Key to Better Patient Outcomes

   Aug 4, 2026

   Greg O'Neill, Director of Patient & Family Health Education at ChristianaCare, discusses how health literacy and effective communication drive better patient outcomes in healthcare systems. Drawing on his background as an ICU nurse and advanced practice nurse, Greg explains ChristianaCare's approach to embedding plain language, personalized content, and technology into clinical workflows while maintaining the human connection essential to trust. He explores AI's potential to reduce cognitive burden for patients, break down fragmented care systems, and highlights the partnership with FDB on multilingual medication calendars as a practical example of health literacy-centered digital tools.

2. Episode 218 – Using Multimodal Foundations and Ambient AI to Scale Clinical Impact

   Jul 28, 2026

   Umesh Rasogi, General Manager of Microsoft Healthcare and Life Sciences, discusses the development and deployment of Dragon Copilot, an AI clinical assistant designed specifically for nursing workflows. The episode explores how multimodal AI foundations and ambient listening technology can reduce nurse burnout and administrative burden, while addressing the critical balance between innovation velocity and responsible AI governance in healthcare settings.

3. Episode 217 – Building Trust in the Next Generation of Healthcare AI

   Jul 21, 2026

   Dr. Heather Varech, a cardiologist and Program Manager at ARPA-H, discusses the Advocate program—a federal initiative to develop patient-facing generative AI for clinical care, specifically targeting heart failure management. The conversation explores how ARPA-H bridges the gap between rapid AI innovation and traditional regulatory pathways, emphasizing the need for ambitious yet scoped projects, close FDA collaboration, and rigorous evaluation frameworks that build public trust in clinical AI technologies.

4. Podcast | Anne Snowdon, SCAN Health | HIMSS: The Shift from Deterministic Care to AI Predictions

   Jul 14, 2026

5. Podcast | Dr. Anne Snowdon | SCAN Health | HIMSS: Future is Connected, Evidence-Based Healthcare

   Jul 13, 2026

6. Podcast | Naomi Fried, PharmStars: Bridging Pharma and Startups to Scale Digital Health Innovation

   Jul 6, 2026

7. Podcast | Dhruv Khullar, M.D., Weill Cornell Medicine: Using AI to Bring Empathy Back to Healthcare

   Jun 29, 2026

8. Podcast | Dhruv Khullar, M.D., Weill Cornell Medicine: Trust, Technology & the Future of Medicine

   Jun 29, 2026

9. Podcast | Julie Demaree, St. Mary’s Healthcare: Solve Problems, Don't Chase Tech

   Jun 24, 2026

10. Podcast|Julie Demaree, St. Mary’s Healthcare: Innovation is About Solving Problems, Not Chasing Tech

    Jun 24, 2026