a16z (Andreessen Horowitz)

86 episodes scanned. 100% of ad slots promote the show's own products.

Recent Episodes

1. Andrew Huberman’s Three Rules for Better Health and Focus

   Nov 3, 2026

   Neuroscientist Andrew Huberman joins a16z partner Daisy Wolf to walk through his daily health routine, covering morning light, meditation, resistance training, nutrition, supplements, and sleep. They also discuss his struggles, such as keeping his social media on a separate phone in a lockbox, and why health protocols should support rather than take over a person's life. The conversation closes with his evidence-based advice for founders, centered on identifying and protecting peak cognitive hours and the potential of neurotechnology for managing sleep and focus.

2. The Robots Already Working in American Factories | Tutor Intelligence

   Nov 2, 2026

   Josh Gruenstein, CEO and co-founder of Tutor Intelligence, explains the company's approach to building general-purpose robots: deploying robots into factories and warehouses, using human teleoperators ("tutors") when needed, and turning that work into training data. The conversation covers the company's two robot models (Cassie and Sunny), its 100-robot data factory, pricing and adoption in manufacturing and logistics, and the hardware and supply chain choices behind the platform. The discussion also touches on the state of robot AI models and U.S. manufacturing's dependence on China.

3. How Bending Spoons Built a $20 Billion Compounder | Luca Ferrari

   Nov 1, 2026

   Bending Spoons co-founder and CEO Luca Ferrari joins a16z General Partner Anish Acharya at Wave by Vento to explain how the company acquires technology products, moves them onto a shared platform, improves their cash generation, and reinvests the cash into new acquisitions. The conversation covers the tradeoffs between invention and optimization, growth versus free cash flow, the company's use of debt, and whether AI threatens established SaaS businesses. Ferrari also describes how Bending Spoons uses AI across customer support, data analysis, and coding.

4. Can AI Fix Professional Networking? | Inside Cosign

   Oct 31, 2026

   Dhruv Gupta and David Booth, both from a16z New Media, join host Sofia on MTS to introduce the Cosign Awards, which recognize operators, companies, and products based on peer nominations. They also discuss Cosign's broader goal of mapping professional relationships that rarely appear in public data and making that graph accessible to both humans and AI agents. The conversation covers how agent-to-agent introductions could eventually match people and companies based on mutual intent.

5. Why AI Could Turn Small Law Firms Into Billion-Dollar Businesses

   Oct 30, 2026

   Eve CEO Jay Madheswaran joins a16z General Partner Alex Rampell to explain how Eve's legal AI handles plaintiff law work from first client call through settlement. They discuss why contingency-fee economics leave many claims unrepresented, and how one Los Angeles firm reportedly raised its caseload per attorney from about 100 to 500. The conversation also covers outcome-based pricing, data and privacy constraints, and how defense insurers may respond as agents negotiate with one another.

6. The Startups Rebuilding American Industry | The AD50

   Oct 29, 2026

   a16z's Erin Price-Wright and Connor Love discuss the a16z AD50 list of American dynamism companies, focused on rebuilding the U.S. industrial base across critical materials, factories, and end systems. The conversation covers how defense demand can help finance manufacturing capacity that later serves commercial markets, how AI and software are changing factory and mining operations, and how private capital is funding physical infrastructure before government demand is guaranteed. They also address founder lineage from SpaceX, Tesla, Anduril, and Palantir, and the challenges of building in the physical world.

7. Mark Cuban on Why AI Could Turn Solo Founders Into Trillionaires

   Oct 28, 2026

   Mark Cuban joins a16z hosts Julie Yoo and Erik Torenberg to discuss his work building Cost Plus Drugs, which he says rests on trust and transparency rather than marketing. The conversation covers the company's growth from 111 generic drugs to about 4,000 SKUs, its drug manufacturing pods, and its direct hospital contracts. They also discuss AI's limits in fixing healthcare's opaque pricing and vertically integrated insurers, employer contract review, personalized medicine, and policy ideas for reform.

8. Reinventing School for the AI Era | Joe Liemandt, Gagan Biyani & Erik Torenberg

   Oct 27, 2026

   Alpha School founder Joe Liemandt discusses a K-12 model in which students spend about two hours a day on core academics through an AI-driven learning engine, then spend the rest of the day on projects that build life skills like teamwork, entrepreneurship, and communication. He and Gagan Biyani, co-founder of Horowitz and Andreessen Academy, compare how these principles could apply to college-age students, including the role of motivation, building real things, and relationships. The conversation also covers how parents are weighing traditional paths against alternatives, and Liemandt's argument that AI will drive an explosion in entrepreneurship.

9. OpenAI: When AI Agents Use Computers Faster Than You

   Oct 26, 2026

   Ari Weinstein and James Sun of OpenAI join a16z's Seema Amble and Fabrizio Serafini to discuss computer-using agents, which can now operate software through the same interface humans use, often faster than an average user. The conversation covers enterprise use cases such as legacy ERPs, procurement, and finance reconciliation, along with deterministic sandboxing, human-in-the-loop controls, and auditability for enterprise deployments. They also discuss how consumer products like Dot might evolve toward more proactive, background, and real-time collaborative agents.

10. The New Startup Playbook | Box CEO Aaron Levie

    Oct 25, 2026

    Box CEO Aaron Levie argues that AI agents let very small teams produce output that once required large companies, giving startups a window to outrun incumbents. He discusses founders shifting from doing the work themselves to orchestrating agents, the growing premium on strategy, taste, and clear specifications, and why he expects specialized agents across nearly every industry and job function. The conversation also covers why enterprise is likely to capture most AI progress and why distribution remains a durable requirement for startups.